Lazareth follows Lee (Ashley Judd), an aunt whose life mission is to protect her orphaned nieces, Imogen and Maeve, from a self-destructing world, raising them in isolation until an outsider threatens their peaceful existence.
A group of young adults spend the weekend at a friend's house by the lake. Joined by the local sheriff, the group encounters an escaped convict Native American chief, a copycat killer and the return of the terrifying masked stalker, Damon.